Preclinical vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome
| Autor: | Josep Font, Concepció Bru, M. Rosa Gilabert, Daniel Zambón, Ricard Cervera, Joan Carles Reverter, M. Angels García-Criado, Dolors Tàssies, Sònia Jiménez, Emilio Ros |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Systemic disease Pathology Apolipoprotein B Arteriosclerosis Hyperlipidemias Blood Sedimentation Gastroenterology Coronary artery disease Rheumatology Risk Factors Antiphospholipid syndrome Internal medicine medicine Humans Lupus Erythematosus Systemic Carotid Stenosis Pharmacology (medical) Vascular Diseases Triglycerides Apolipoproteins B Ultrasonography Autoimmune disease biology Vascular disease business.industry Age Factors Middle Aged Antiphospholipid Syndrome medicine.disease Tunica intima Connective tissue disease C-Reactive Protein Carotid Arteries Cholesterol medicine.anatomical_structure Hypertension biology.protein Female business |
| Zdroj: | Rheumatology. 44:756-761 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective. To determine the prevalence of preclinical vascular disease and associated risk factors in patients with systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS). Methods. We consecutively studied 70 SLE patients and 25 primary APS patients without clinical coronary artery disease. The control group included 40 healthy women. Carotid ultrasound was performed and the intima-media wall thickness (IMT) and presence of plaque was investigated in all patients and controls. Traditional vascular risk factors and SLE-disease and treatment related factors were also analysed. Results. SLE patients had a higher prevalence of traditional atherosclerosis risk factors: hypertension (P_0.005) and dyslipidaemia (P_0.05) and higher levels of total cholesterol (P^ 0.03), triglycerides (P^ 0.004) and apolipoprotein B (P^ 0.04). The prevalence of carotid plaque was higher and appeared earlier in SLE patients than in the primary APS patients or controls (P_0.001). The IMT was similar in the three groups. SLE patients with secondary APS had a higher prevalence of carotid plaque than patients with primary APS (37.5% vs 8%, P^ 0.03). The presence of plaque in SLE patients was associated with a higher SLICC score (2.40 1.78 vs 1.02 1.18, P^ 0.002), higher ECLAM score (3.10 2.32 vs 1.84 1.59, P^ 0.02) and older age (47.3 8.44 vs 37.38 11.28, P^ 0.003) at the time of carotid ultrasound study. Conclusion. Plaque prevalence in patients with primary APS is similar to that of controls and inferior to that of SLE patients with secondary APS. SLE patients have a high prevalence of early carotid atherosclerosis that is associated with cumulative disease damage and disease activity. |
| Databáze: | OpenAIRE |
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