Internal Flow Choking in Cardiovascular System: A Radical Theory in the Risk Assessment of Asymptomatic Cardiovascular Diseases
| Autor: | Charlie Oommen, Rajaghatta Sundararam Bharath, Nichith Chandrasekaran, Valsalayam Raghavapanicker Sanal Kumar, Shiv Kumar Choudhary, Ajith Sukumaran, Pradeep Kumar Radhakrishnan, Vigneshwaran Sankar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Internal flow InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL 030204 cardiovascular system & hematology medicine.disease Asymptomatic System a 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine medicine.symptom Risk assessment Choking Intensive care medicine business GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) |
| Popis: | The theoretical discovery of Sanal flow choking in the cardiovascular system (CVS) demands for interdisciplinary studies and universal actions to propose modern medications and to discover new drugs to annul the risk of flow-choking leading to shock-wave generation causing asymptomatic-cardiovascular-diseases. In this chapter we show that when blood-pressure-ratio (BPR) reaches the lower-critical-hemorrhage-index (LCHI) the flow-choking could occur in the CVS with and without stent. The flow-choking is uniquely regulated by the biofluid/blood-heat-capacity-ratio (BHCR). The BHCR is well correlated with BPR, blood-viscosity and ejection-fraction. The closed-form analytical models reveal that the relatively high and the low blood-viscosity are cardiovascular-risk factors. In vitro data shows that nitrogen, oxygen, and carbon dioxide gases are predominant in fresh blood samples of the human being/Guinea-pig at a temperature range of 37–40 °C (98.6–104 °F). In silico results demonstrate the occurrence of Sanal flow choking leading to shock wave generation and pressure-overshoot in CVS without any apparent occlusion. We could conclude authoritatively, without any ex vivo or in vivo studies, that the Sanal flow choking in CVS leads to asymptomatic-cardiovascular-diseases. The cardiovascular-risk could be diminished by concurrently lessening the viscosity of biofluid/blood and flow-turbulence by increasing the thermal-tolerance level in terms of BHCR and/or by decreasing the BPR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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