A comparison of manual and remote afterloading in the treatment of carcinoma of the cervix: increasing dose rate with a flexible applicator
| Autor: | O.S. Wong, T.J. Whelan, J.F. Filbee, S. Voruganti, J.F. Jeffrey, P.J. Joseph, J.E. Aldrich |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Brachytherapy Uterine Cervical Neoplasms Carcinoma medicine Humans Radiology Nuclear Medicine and imaging Cervix neoplasm Stage (cooking) Cervix Aged Cervical cancer Aged 80 and over business.industry Radiotherapy Dosage Middle Aged medicine.disease Surgery Radiation therapy medicine.anatomical_structure Oncology Female Nuclear medicine business Dose rate |
| Zdroj: | Clinical oncology (Royal College of Radiologists (Great Britain)). 4(5) |
| ISSN: | 0936-6555 |
| Popis: | A historical cohort design was used to assess the effect of introducing a remote afterloading system with a flexible applicator for the intracavitary treatment of cervical cancer. One hundred and sixty-eight patients treated for the 5 years prior to its introduction were compared to 84 patients treated for the first 3 years of its use. Patients were comparable with respect to age and stage. Treatment policies and techniques remained the same during the study period. Average dose rate to point A increased from 0.46 Gy/hr to 0.67 Gy/hr. The 3-year actuarial survival was equivalent between the two treatment modalities: 67.7% (manual), and 60.6% (remote). Patterns of local recurrence and distant failure were also equivalent between the two groups. Severe complication rates were comparable (8.3% manual, 6.3% remote) despite the increase in dose rate, confirming that the remote afterloading system can be safely adapted to a flexible applicator. The introduction of the remote afterloading system resulted in a 72% reduction in radiation exposure to staff. |
| Databáze: | OpenAIRE |
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