Clustering of male infertility in the families of couples treated with intracytoplasmic sperm injection
| Autor: | Jürgen Horst, D. Meschede, Hermann M. Behre, Eberhard Nieschlag, B. Lemcke, Ch. De Geyter |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Infertility
Adult Male medicine.medical_specialty Offspring medicine.medical_treatment media_common.quotation_subject Fertility Biology Intracytoplasmic sperm injection Medical Records Male infertility Cohort Studies Reference Values medicine Cluster Analysis Humans Genetic Testing Sperm Injections Intracytoplasmic Family history Infertility Male media_common Gynecology Rehabilitation Obstetrics and Gynecology Family aggregation medicine.disease Fertility problems Reproductive Medicine Female |
| Zdroj: | Human reproduction (Oxford, England). 15(7) |
| ISSN: | 0268-1161 |
| Popis: | Intracytoplasmic sperm injection (ICSI) is an effective treatment modality for male factor infertility, but it could promote the transgenerational transmission of genetic defects causing gametogenic failure. Cytogenetic and molecular techniques permit the diagnosis of some infertility-causing genetic aberrations, but many more probably evade detection with currently available technology. The analysis of the recurrence pattern of infertility in infertile couples' families could define the importance of heritable factors in the pathogenesis of human infertility. We have subjected 621 consecutive infertile couples treated with ICSI in a single institution to a comprehensive genetic workup including documentation of the family history, karyotyping and various DNA tests. In all, 1302 fertile couples served as controls. Of the infertile couples 6.4% were shown to have a fertility problem with a definite genetic basis. Male, but not female fertility problems displayed a distinct pattern of familial aggregation. In addition, the infertile couples had fewer siblings than the fertile controls, a finding compatible with suboptimal fertility already among the infertile couples' parents. In summary, our data indicate that male factor infertility should be considered a potentially heritable condition. The recurrence risk for infertility in the offspring of couples treated with ICSI might be substantial. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|