Increasing top-down suppression from prefrontal cortex facilitates tactile working memory
| Autor: | Hanne S. Antila, Tuomas Neuvonen, Synnöve Carlson, Antti Pertovaara, Yuanye Ma, Petri Savolainen, Oili Salonen, Henri Hannula, Jaana Hiltunen |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Sensory processing Cognitive Neuroscience medicine.medical_treatment Prefrontal Cortex Somatosensory system behavioral disciplines and activities Executive Function Young Adult 03 medical and health sciences 0302 clinical medicine Evoked Potentials Somatosensory Skin Physiological Phenomena Memory improvement Neural Pathways Image Processing Computer-Assisted Reaction Time medicine Humans Middle frontal gyrus Prefrontal cortex 030304 developmental biology 0303 health sciences Working memory Human brain Transcranial Magnetic Stimulation Electric Stimulation Transcranial magnetic stimulation Electrooculography Diffusion Magnetic Resonance Imaging Memory Short-Term medicine.anatomical_structure Neurology Touch Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage. 49:1091-1098 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2009.07.049 |
| Popis: | Navigated transcranial magnetic stimulation (TMS) combined with diffusion-weighted magnetic resonance imaging (DW-MRI) and tractography allows investigating functional anatomy of the human brain with high precision. Here we demonstrate that working memory (WM) processing of tactile temporal information is facilitated by delivering a single TMS pulse to the middle frontal gyrus (MFG) during memory maintenance. Facilitation was obtained only with a TMS pulse applied to a location of the MFG with anatomical connectivity to the primary somatosensory cortex (S1). TMS improved tactile WM also when distractive tactile stimuli interfered with memory maintenance. Moreover, TMS to the same MFG site attenuated somatosensory evoked responses (SEPs). The results suggest that the TMS-induced memory improvement is explained by increased top-down suppression of interfering sensory processing in S1 via the MFG-S1 link. These results demonstrate an anatomical and functional network that is involved in maintenance of tactile temporal WM. |
| Databáze: | OpenAIRE |
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