Recombinant Activated Coagulation Factor VII and Prothrombin Complex Concentrates Are Equally Effective in Reducing Hematoma Volume in Experimental Warfarin-Associated Intracerebral Hemorrhage
| Autor: | Waltraud Pfeilschifter, Kazuhide Hayakawa, Eng H. Lo, Elizabeth M. Van Cott, Frieder Schlunk, Christian Foerch |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_treatment Article Mice chemistry.chemical_compound Hematoma medicine Animals Collagenases Saline Cerebral Hemorrhage Advanced and Specialized Nursing Intracerebral hemorrhage Hemostasis Factor VII business.industry Warfarin Brain medicine.disease Blood Coagulation Factors Treatment Outcome chemistry Anesthesia Collagenase Neurology (clinical) Hemoglobin Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Stroke. 43:246-249 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background and Purpose— Based on an experimental model of warfarin-associated intracerebral hemorrhage, we investigated whether the rapid reversal of anticoagulation using prothrombin complex concentrates (PCC) or recombinant activated coagulation factor VII (rFVIIa) reduces hematoma volume. Methods— Mice were orally pretreated with warfarin (2 mg/kg). Intracerebral hemorrhage was induced by collagenase injection into the right striatum. Forty-five minutes later, PCC (100 IE/kg), rFVIIa (1 mg/kg), or an equal volume of saline was administered intravenously. Hematoma volume after 24 hours was quantified using a photometric hemoglobin assay. Results— International normalized ratio was 4.3±0.4 in saline-treated mice, 0.9±0.1 in rFVIIa mice, and 1.4±0.2 in PCC mice. Intracerebral hemorrhage volume was 29.0±19.7 μL in the saline group (n=7), 8.6±4.3 μL in the rFVIIa group (n=6), and 6.1±1.8 μL in the PCC group (n=7; analysis of variance between-group differences P =0.004; post hoc rFVIIa versus saline P =0.021; PCC versus saline P =0.007). No significant difference was found between PCC- and rFVIIa-treated animals. Conclusions— Our results suggest that PCC and rFVIIa are equally effective in restoring coagulation and preventing excessive hematoma growth in acute warfarin-associated intracerebral hemorrhage. |
| Databáze: | OpenAIRE |
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