Respiratory Cancer in a Cohort of Copper Smelter Workers: Results from More Than 50 Years of Follow-up
| Autor: | Linda M. Pottern, Joseph F. Fraumeni, B. J. Stone, Jay H. Lubin |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Epidemiology Occupational disease Physiology chemistry.chemical_element Air Pollutants Occupational Arsenic Humans Sulfur Dioxide Medicine Respiratory system Risk factor Aged Cause of death Aged 80 and over Montana Inhalation business.industry Respiratory disease Middle Aged medicine.disease Respiratory Tract Neoplasms Surgery Occupational Diseases chemistry Relative risk Metallurgy Regression Analysis business Copper Follow-Up Studies |
| Zdroj: | American Journal of Epidemiology. 151:554-565 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/oxfordjournals.aje.a010243 |
| Popis: | Several studies have linked inhalation of airborne arsenic with increased risk of respiratory cancer, but few have analyzed the shape of the exposure-response curve. In addition, since inhaled airborne arsenic affects systemic levels of inhaled arsenic, there is concern that inhaled arsenic may be associated with cancers of the skin, bladder, kidney, and liver, which have been linked to ingested arsenic. The authors followed 8,014 white male workers who were employed for 12 months or more prior to 1957 at a Montana copper smelter from January 1, 1938 through December 31, 1989. A total of 4,930 (62%) were deceased, including 446 from respiratory cancer. Significantly increased standardized mortality ratios (SMRs) were found for all causes (SMR = 1.14), all cancers (SMR = 1.13), respiratory cancer (SMR = 1.55), diseases of the nervous system and sense organs (SMR = 1.31), nonmalignant respiratory diseases (SMR = 1.56), emphysema (SMR = 1.73), ill-defined conditions (SMR = 2.26), and external causes (SMR = 1.35). Internal analyses revealed a significant, linear increase in the excess relative risk of respiratory cancer with increasing exposure to inhaled airborne arsenic. The estimate of the excess relative risk per mg/m3-year was 0.21/(mg/m3-year) (95% confidence interval: 0.10, 0.46). No other cause of death was related to inhaled arsenic exposure. |
| Databáze: | OpenAIRE |
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