PROTECTIVE EFFECT OF RESVERATROL ON ETHANOL-INDUCED LIPID PEROXIDATION IN RATS
| Autor: | E. Aouani, A. Kamoun, M. Hammami, B. Mornagui, N. Gharbi, S. El-Fazaa, A. Kasdallah-Grissa |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Intraperitoneal injection Pharmacology Resveratrol medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound Malondialdehyde Stilbenes medicine Animals Rats Wistar chemistry.chemical_classification Ethanol Phytoalexin Central Nervous System Depressants General Medicine Diet Rats chemistry Biochemistry Dietary Supplements Lipid Peroxidation Oxidative stress |
| Zdroj: | Alcohol and Alcoholism. 41:236-239 |
| ISSN: | 1464-3502 0735-0414 |
| DOI: | 10.1093/alcalc/agh256 |
| Popis: | Aim: Chronic ethanol treatment induces an increase in oxidative stress. As polyphenolic compounds are potent antioxi- dants, we aimed to examine whether dietary supplementation of resveratrol may attenuate lipid peroxidation, the major end-point of oxidative damage resulting from chronic ethanol administration. Method: Three groups of male Wistar rats were used. The first group served as control and received a daily intraperitoneal injection of 0.9% saline. The second group of rats was daily injected with 35% ethanol at 3 g/kg body weight. The third group was given the same dose of ethanol and supplemented with resveratrol (5 g/kg) in the standard diet. Malondialdehyde (MDA), an indicator of oxidative stress, was measured in the liver, heart, brain, and testis. Results: At the end of a 6 weeks treatment period, MDA levels were significantly increased by 51.5, 53.7, 72.7, and 40.5% in the liver, heart, brain, and testis, respectively. However, when ethanol treated rats were given resveratrol the increase in MDA levels was significantly reduced in all organs to nearly those of control rats. Conclusion: Resveratrol is able to inhibit the ethanol-induced lipid peroxidation and have protective effect against oxidative injury. |
| Databáze: | OpenAIRE |
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