Discordant CSF/plasma HIV-1 RNA in individuals on virologically suppressive antiretroviral therapy in Western India
| Autor: | Uma Mahajan, Chinmay Saraf, Kartik Natrajan, Sachin D. Kore, Niranjan M. Rathod, Ameet Dravid, Rustom S. Wadia, Milind M. Kulkarni, Umakant S. Mahajan |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty nadir CD4 count Anti-HIV Agents 030106 microbiology protease inhibitors Observational Study India Viremia HIV Infections Drug resistance antiretroviral therapy (ART) Gastroenterology 03 medical and health sciences low-level viremia (LLV) 0302 clinical medicine Cerebrospinal fluid Interquartile range Central Nervous System Diseases Internal medicine Blood plasma medicine CNS penetration effectiveness (CPE) score Prevalence HIV encephalopathy Humans 030212 general & internal medicine CSF/plasma HIV-1 RNA discordance Retrospective Studies business.industry Retrospective cohort study General Medicine Middle Aged Viral Load medicine.disease Regimen HIV-1 RNA Viral Female business Viral load Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Aim of this study was to estimate the prevalence of cerebrospinal fluid (CSF)/Plasma HIV-1 RNA discordance in virologically suppressed individuals presenting with incident neurologic symptoms. In this retrospective cohort study conducted between March 1, 2009, and March 1, 2017, HIV-1 infected adults exposed to atleast 12 months of antiretroviral therapy (ART) and having plasma viral load (VL) 20 copies/mL) with an undetectable plasma RNA (complete viral suppression, VL ≤20 copies/mL) or CSF HIV-1 RNA ≥ 0.5 log10 higher than plasma RNA when plasma VL was between 20 and 1000 copies/mL (low-level viremia, LLV). Out of 1584 virologically suppressed patients, 71 (4.4%) presented with incident neurologic symptoms. Twenty out of 71 (28.2%) patients were diagnosed with CSF/Plasma HIV-1 discordance. Median plasma and CSF VL in patients with discordance was 120 [interquartile range (IQR) |
| Databáze: | OpenAIRE |
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