Revisiting immune escape in colorectal cancer in the era of immunotherapy

Autor: Hans Morreau, Marieke E. Ijsselsteijn, Catherine Sautès-Fridman, Florent Petitprez, Noel Filipe da Cunha Carvalho de Miranda, Ruud van der Breggen, Laetitia Lacroix, Catherine Julie, Wolf H. Fridman, Dina Ruano
Přispěvatelé: Leiden University Medical Center (LUMC), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Sorbonne Paris Cité (USPC), Ligue Nationale Contre le Cancer - Paris, Ligue Nationnale Contre le Cancer, Service de pathologie [CHU Ambroise Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP]
Rok vydání: 2019
Předmět:
Male
Cancer Research
Carcinogenesis
Colorectal cancer
T-Lymphocytes
medicine.medical_treatment
Antigen presentation
Genes
MHC Class I
[SDV.CAN]Life Sciences [q-bio]/Cancer
Human leukocyte antigen
Brief Communication
medicine.disease_cause
Metastasis
03 medical and health sciences
0302 clinical medicine
Immunoediting
Neoplastic Syndromes
Hereditary
medicine
Humans
Neoplasm Metastasis
Oncogenesis
Regulation of gene expression
Antigen Presentation
Brain Neoplasms
Immune evasion
business.industry
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
Immunotherapy
Middle Aged
medicine.disease
Phenotype
digestive system diseases
3. Good health
Blockade
Gene Expression Regulation
Neoplastic
Genes
cdc
Liver
Oncology
030220 oncology & carcinogenesis
Cancer research
Female
Colorectal Neoplasms
business
Zdroj: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 120 (8), pp.815-818. ⟨10.1038/s41416-019-0421-x⟩
British Journal of Cancer, 120(8), 815-818. NATURE PUBLISHING GROUP
ISSN: 1532-1827
0007-0920
DOI: 10.1038/s41416-019-0421-x
Popis: International audience; In colorectal cancer (CRC), T-cell checkpoint blockade is only effective in patients diagnosed with mismatch repair-deficient (MMR-d) cancers. However, defects in Human Leukocyte Antigen (HLA) class I expression were reported to occur in most MMR-d CRCs, which would preclude antigen presentation in these tumours, considered essential for the clinical activity of this immunotherapeutic modality. We revisited this paradox by characterising HLA class I expression in two independent cohorts of CRC. We determined that loss of HLA class I expression occurred in the majority (73-78%) of MMR-d cases. This phenotype was rare in CRC liver metastases, irrespective of MMR status, whereas weak, inducible expression of HLA class I molecules was frequent in liver lesions. We propose that HLA class I is an important determinant of metastatic homing in CRCs. This observation is paramount to understand CRC carcinogenesis and for the application of immunotherapies in the metastatic setting.
Databáze: OpenAIRE
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