Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats
| Autor: | Sérgio Henrique Sousa Santos, Alanna Fernandes Paraíso, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Pablo Vinicyus Ferreira Chagas, Deborah de Farias Lelis, Wagner Leite Ferreira, João Marcus Oliveira Andrade, Thaísa Soares Crespo, Antonio Sergio Barcala Jorge |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Tecido adiposo medicine.medical_treatment Angiotensinogen Adipose tissue Sistema renina-angiotensina White adipose tissue Peptidyl-Dipeptidase A Diet High-Fat Biochemistry Renin-Angiotensin System 03 medical and health sciences Structural Biology Weight loss Gastrectomy Internal medicine Renin–angiotensin system Weight Loss medicine Animals Humans Obesity Rats Wistar Gastrectomia 030109 nutrition & dietetics Angiotensin II receptor type 1 biology Cirurgia bariátrica Tumor Necrosis Factor-alpha Insulin Interleukins Angiotensin-converting enzyme General Medicine Endocrinology Obesidade Adipose Tissue Angiotensin-converting enzyme 2 biology.protein Metabolome medicine.symptom |
| Zdroj: | Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| ISSN: | 1875-5305 |
| Popis: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Background: sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. Objectives: the present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Methods: male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated. Results: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors. Conclusion: this study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG. |
| Databáze: | OpenAIRE |
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