Discovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A1 Receptor Antagonist with Potent Diuretic Activity
| Autor: | Takao Terai, Takahiro Kusunoki, Takafumi Mitsunaga, Takeshi Kato, Youichi Shiokawa, Atsushi Akahane, Keizo Yoshida, Yasuhiro Kita, Takayoshi Kinoshita, Hirohito Katayama |
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| Rok vydání: | 1999 |
| Předmět: |
Pyridines
Stereochemistry Carboxylic acid medicine.medical_treatment Administration Oral Pharmacology Chemical synthesis Rats Sprague-Dawley Structure-Activity Relationship chemistry.chemical_compound Adenosine A1 receptor In vivo Drug Discovery Pyrazolopyridine medicine Animals Diuretics chemistry.chemical_classification Chemistry Antagonist Xanthine Rats Purinergic P1 Receptor Antagonists Drug Design Pyrazoles Molecular Medicine Diuretic |
| Zdroj: | Journal of Medicinal Chemistry. 42:779-783 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm980671w |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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