Effect of sodium nitroprusside on hypoxic pulmonary vasoconstriction in the dog
| Autor: | M. M. Hansen, J. P. Leventhal, G. H. Parsons, J. D. Goldstein |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Nitroprusside
Pentobarbital Time Factors Supine position Physiology medicine.medical_treatment Femoral vein Dogs Physiology (medical) Hypoxic pulmonary vasoconstriction medicine Animals Ferricyanides Hypoxia Lung Mechanical ventilation Dose-Response Relationship Drug business.industry Hypoxia (medical) medicine.anatomical_structure Vasoconstriction Anesthesia Vascular resistance Sodium nitroprusside medicine.symptom business medicine.drug |
| Zdroj: | Journal of Applied Physiology. 51:288-292 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | The objective of the study was to determine the direct actions of sodium nitroprusside (SNP) on the pulmonary vasculature actively constricted by hypoxic ventilation in the closed-chest dog. In 21 supine anesthetized (pentobarbital sodium, 25 mg/kg) dogs the left lower lobe was catheterized with a 20 F wedged-flow catheter. With constant flow to this lung lobe, lobar pulmonary artery pressure (PAP), left ventricular end-diastolic pressure (LVEDP), and lobar pulmonary vascular resistance (PVR) were studied during room air and 10% O2 mechanical ventilation. With lobar flow and LVEDP constant, observed changes of lobar PAP and PVR represent direct effects on vascular tone unaffected by passive factors. Ventilation with 10% O2 resulted in a significant increase in lobar PAP [12.2 +/- 1.6 to 17.2 +/- 1.2 (SE) Torr] and PVR [42.2 +/- 13.3 to 61.2 +/- 15.0 (SE) Torr X 1(-1) X min]. Then during continued hypoxia in 12 animals, femoral vein infusion of SNP at doses of 1, 2, and 5 microgram X kg-1 X min-1 resulted in significant decreases in lobar PAP to 14.8 +/- 1.5, 14.8 +/- 1.5, and 13.4 +/- 1.6 Torr, respectively, and in PVR to 56.7 +/- 14.1, 54.0 +/- 13.9, and 47.8 %/- 13.2 Torr X 1(-1) X min, respectively. In six animals the sequence of drug infusion was then reversed with similar results. It is concluded that the actively constricted pulmonary vascular bed is directly dilated by SNP infusion. |
| Databáze: | OpenAIRE |
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