Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study
| Autor: | Cari M. Kitahara, Dóra Kӧrmendiné Farkas, Jens Otto Lunde Jørgensen, Henrik Toft Sørensen, Deirdre Cronin-Fenton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Thyroiditis Goiter endocrine system diseases Endocrinology Diabetes and Metabolism Denmark Clinical Biochemistry Hypothyroidism/complications Biochemistry Gastroenterology Hyperthyroidism Hyperthyroidism/complications Cohort Studies 0302 clinical medicine Endocrinology Registries Thyroid cancer Thyroid disease Incidence Thyroid Middle Aged medicine.anatomical_structure 030220 oncology & carcinogenesis Female Thyroid nodules Adult Risk medicine.medical_specialty endocrine system Adenoma 030209 endocrinology & metabolism Thyroid Neoplasms/epidemiology 03 medical and health sciences Sex Factors Hypothyroidism Internal medicine medicine Humans Thyroid Neoplasms Clinical Research Articles Aged business.industry Biochemistry (medical) medicine.disease Denmark/epidemiology Cancer registry Thyroiditis/complications business |
| Zdroj: | Kitahara, C M, Komendiné Farkas, D, Jørgensen, J O L, Cronin-Fenton, D & Sørensen, H T 2018, ' Benign Thyroid Diseases and Risk of Thyroid Cancer : A Nationwide Cohort Study ', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 6, pp. 2216-2224 . https://doi.org/10.1210/jc.2017-02599 |
| DOI: | 10.1210/jc.2017-02599 |
| Popis: | Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk.Objective: To examine thyroid cancer risk after diagnoses of a wide range of benign thyroid conditions.Design: Hospital and cancer registry linkage cohort study for the years 1978 to 2013.Setting: Nationwide (Denmark).Participants: Patients diagnosed with hyperthyroidism (n = 85,169), hypothyroidism (n = 63,143), thyroiditis (n = 12,532), nontoxic nodular goiter (n = 65,782), simple goiter (n = 11,582), other/unspecified goiter (n = 21,953), or adenoma (n = 6,481) among 8,258,807 residents of Denmark during the study period.Main Outcome Measures: We computed standardized incidence ratios (SIRs) for differentiated thyroid cancer, excluding the first 12 months of follow-up after benign thyroid disease diagnosis.Results: SIRs were significantly elevated for all benign thyroid diseases apart from hypothyroidism. SIRs were higher for men than women and in the earlier follow-up periods. Elevated SIRs were observed for localized and regional/distant thyroid cancer. After excluding the first 10 years of follow-up, hyperthyroidism [n = 27 thyroid cancer cases; SIR = 2.00; 95% confidence interval (CI): 1.32 to 2.92], nontoxic nodular goiter (n = 83; SIR = 4.91; 95% CI: 3.91 to 6.09), simple goiter (n = 8; SIR = 4.33; 95% CI: 1.87 to 8.53), other/unspecified goiter (n = 20; SIR = 3.94; 95% CI: 2.40 to 6.08), and adenoma (n = 9; SIR = 6.02; 95% CI: 2.76 to 11.5) remained positively associated with thyroid cancer risk.Conclusions: We found an unexpected increased risk of differentiated thyroid cancer, including regional/distant disease, following diagnosis of hyperthyroidism and thyroiditis that could not be solely attributed to increased medical surveillance. Hypothyroidism was less clearly associated with thyroid cancer risk. |
| Databáze: | OpenAIRE |
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