Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients
| Autor: | Fotios Kalfarentzos, Ioannis Habeos, Anastasia E. Kottorou, Petros Constantinopoulos, Venetsana Kyriazopoulou, Marina Michalaki, Agathoklis Psyrogiannis |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Bariatric Surgery Adipose tissue Context (language use) Severity of Illness Index Endocrinology Blood serum Glucocorticoid receptor Internal medicine medicine Humans Tissue Distribution Obesity Prospective Studies Saliva Metabolic Syndrome business.industry Area under the curve General Medicine Middle Aged medicine.disease Female Metabolic syndrome business Biomarkers medicine.drug |
| Zdroj: | European Journal of Endocrinology. 172:69-78 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-14-0626 |
| Popis: | ContextAdrenal and extra-adrenal cortisol production may be involved in the development of metabolic syndrome (MetS).ObjectiveTo investigate the activity of the hypothalamic–pituitary–adrenal (HPA) axis and the expression of HSD11B1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptors) α (NR3C1α) and β (NR3C1β) in the liver, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of severely obese patients with and without MetS.MethodsThe study included 37 severely obese patients (BMI ≥40 kg/m2), 19 with MetS (MetS+ group) and 18 without (MetS− group), studied before and during bariatric surgery. Before the day of surgery, urinary free cortisol (UFC) and diurnal variation of serum and salivary cortisol were estimated. During surgery, biopsies of the liver, VAT and SAT were obtained. The expression of HSD11B1, NR3C1α and NR3C1β was evaluated by RT-PCR.ResultsUFC and area under the curve for 24-h profiles of serum and salivary cortisol were lower in the MetS− group. In the MetS− group, mRNA levels ofHSD11B1in liver exhibited a negative correlation with liver NR3C1α (LNR3C1α) and VAT expression of HSD11B1 was lower than the MetS+ group.ConclusionsWe observed a downregulation of the NR3C1α expression and lower VAT mRNA levels ofHSD11B1in the MetS− group, indicating a lower selective tissue cortisol production and action that could protect these patients from the metabolic consequences of obesity. In the MetS− group, a lower activity of the HPA axis was also detected. Taken together, cortisol in tissue and systematic level might play a role in the development of MetS in severely obese patients. |
| Databáze: | OpenAIRE |
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