Regulation of Thermogenic Adipocyte Differentiation and Adaptive Thermogenesis Through Histone Acetylation
| Autor: | Belinda X. Ong, Reinhard Brunmeir, Qiongyi Zhang, Xu Peng, Muhammad Idris, Chungang Liu, Feng Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism adaptive thermogenesis 030209 endocrinology & metabolism Review histone deacetylase inhibitors Bioinformatics lcsh:Diseases of the endocrine glands. Clinical endocrinology Energy homeostasis Histones 03 medical and health sciences chemistry.chemical_compound Endocrinology 0302 clinical medicine Adipocyte histone acetyltransferase inhibitors Adipocytes histone deacetylation Animals Humans Epigenetics Histone Acetyltransferases lcsh:RC648-665 Adipogenesis epigenetics biology histone acetylation Acetylation Cell Differentiation Thermogenesis Adaptation Physiological 030104 developmental biology Histone chemistry gene expression biology.protein thermogenic adipocyte differentiation |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 11 (2020) |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2020.00095 |
| Popis: | Over the past decade, the increasing prevalence of obesity and its associated metabolic disorders constitutes one of the most concerning healthcare issues for countries worldwide. In an effort to curb the increased mortality and morbidity derived from the obesity epidemic, various therapeutic strategies have been developed by researchers. In the recent years, advances in the field of adipocyte biology have revealed that the thermogenic adipose tissue holds great potential in ameliorating metabolic disorders. Additionally, epigenetic research has shed light on the effects of histone acetylation on adipogenesis and thermogenesis, thereby establishing the essential roles which histone acetyltransferases (HATs) and histone deacetylases (HDACs) play in metabolism and systemic energy homeostasis. In regard to the therapeutic potential of thermogenic adipocytes for the treatment of metabolic diseases, herein, we describe the current state of knowledge of the regulation of thermogenic adipocyte differentiation and adaptive thermogenesis through histone acetylation. Furthermore, we highlight how different HATs and HDACs maintain the epigenetic transcriptional network to mediate the pathogenesis of various metabolic comorbidities. Finally, we provide insights into recent advances of the potential therapeutic applications and development of HAT and HDAC inhibitors to alleviate these pathological conditions. |
| Databáze: | OpenAIRE |
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