Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile and neurohumoral axis in hypertensive women at reproductive age
| Autor: | Cassiana Rosa Galvão Giribela, E.C. Baracat, Grazia Maria Guerra, N C Mello, Fernanda Marciano Consolim-Colombo, Tercio Lemos de Morais, Marcelo Gil Nisenbaum |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Baroreceptor Population Blood Pressure Ethinyl Estradiol Body Mass Index law.invention Electrolytes Young Adult Randomized controlled trial Heart Rate law Internal medicine Ethinylestradiol Obstetrics and Gynaecology medicine Homeostasis Humans Prospective Studies Prospective cohort study education Aldosterone Antihypertensive Agents Triglycerides education.field_of_study Oral contraceptives business.industry Obstetrics and Gynecology Drospirenone Baroreflex Cardiovascular risk Contraceptives Oral Combined Endocrinology Blood pressure Reproductive Medicine Hypertension Androstenes Female business Hormone medicine.drug |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 182:113-117 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2014.09.006 |
| Popis: | The use of combined oral contraceptives is widespread among hypertensive women despite being associated with increased cardiovascular risk. Contraceptives containing drospirenone, which has antimineralocorticoid properties, may have a positive or neutral effect on neurohumoral activation and metabolic homeostasis of hypertensive women at reproductive age.ObjectivesTo evaluate the effect of combined oral contraceptive containing drospirenone+ethinylestradiol on the systemic blood pressure, metabolic variables and neurohumoral axis in hypertensive women in reproductive age.DesignProspective controlled trial with 56 hypertensive women allocated in two groups: 30 volunteers under oral combined contraceptive use and 26 volunteers using non-hormonal contraceptive methods. Subjects were tested before the introduction of the contraceptive method and 6 months after its use. For data acquisition, we used continuous non-invasive beat-to-beat blood pressure curve recordings and, for the biochemical and hormonal analyses two blood samples were obtained. Student's t test was used to determine differences between groups and moments and p |
| Databáze: | OpenAIRE |
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