Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: Histopathological aspects
| Autor: | Bo Gyun Kim, Young Taek Sohn, Han-Gon Choi, Jong Oh Kim, Tran Tuan Hiep, Jeonghwan Kim, Sae-Kwang Ku, Chul Soon Yong, Dong Won Lee, Eui Seon Do, Hyuk Jun Cho, Miwon Son, Sang Duk Han, Sun Woo Jang, Joon Ho Jun, Min Kyung Kang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Cicatrix Hypertrophic Scars Skin Pigmentation Pantothenic Acid Silicone Gels chemistry.chemical_compound Hypertrophic scar Silicone Drug Discovery medicine Animals Allantoin Skin pigment Skin Heparin Plant Extracts business.industry Organic Chemistry Anatomy medicine.disease Disease Models Animal Drug Combinations chemistry Hypertrophic scarring Molecular Medicine Female Rabbits medicine.symptom Dexpanthenol business Histopathological aspects medicine.drug |
| Zdroj: | Archives of Pharmacal Research. 35:1999-2006 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/s12272-012-1117-4 |
| Popis: | In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna™) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna™-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna™ showed more favorable effects on hypertrophic scars than a commercial product, Contractubex®. Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna™, could be a promising formulation as an effective therapeutic agent for hypertrophic scars. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink