Nicotine self-administration in rats
| Autor: | C Brown, Anthony R. Caggiula, Eric C. Donny, Steven Knopf |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
Male Nicotine Behavior Animal medicine.medical_treatment Pharmacology toxicology Free base Self Administration Extinction (psychology) Rats Sprague dawley Rats Sprague-Dawley Nicotine Bitartrate Anesthesia medicine Animals Nicotinic Agonists Psychology Self-administration Saline medicine.drug |
| Zdroj: | Psychopharmacology. 122(4) |
| ISSN: | 0033-3158 |
| Popis: | Considering the importance of self-administration models in determining mechanisms of drug maintained behavior, we attempted to replicate the findings of nicotine self-administration by Corrigall and Coen. Male, Sprague-Dawley rats, trained on food reinforcement, acquired relatively high and stable rates of self-administration of IV nicotine bitartrate (0.03 mg/kg, free base). Extinction and reacquisition followed substituting saline and then nicotine, respectively. Responses, infusions and intake decreased at 0.003 mg/kg, while intake increased at 0.06 mg/kg. This model of nicotine self-administration provides a reliable alternative to experimenter-administration models for examining the effects of nicotine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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