Hormonal Contribution to Liver Regeneration
| Autor: | Wei Zhou, Anan Abu Rmilah, Scott L. Nyberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
NTBC
2-nitro-4-trifluoro-methyl-benzoyl-1 3-cyclohexanedione Review hESC human embryonic stem cell 030204 cardiovascular system & hematology HPC hepatic progenitor cell PCR polymerase chain reaction 0302 clinical medicine ERK extracellular signal-regulated kinase Epidermal growth factor Medicine 030212 general & internal medicine NOS nitric oxide synthase TGF transforming growth factor CDK cyclin-dependent kinase TNF tumor necrosis factor lcsh:R5-920 FAH fumarylacetoacetate hydrolase mRNA messenger RNA Liver regeneration Ghr-/- growth hormone receptor gene knockout STAT signal transducer and activator of transcription JNK JUN N-terminal kinase Hepatocyte nuclear factors IR insulin receptor EGFR EGF receptor Hepatocyte growth factor HNF hepatocyte nuclear factor lcsh:Medicine (General) medicine.drug PKB protein kinase B PH partial hepatectomy PCNA proliferating cell nuclear antigen mTOR mammalian target of rapamycin 03 medical and health sciences ROS reactive oxygen species hiPSC human induced pluripotent stem cells PI3K/AKT/mTOR pathway EGF epidermal growth factor T3 triiodothyronine business.industry Regeneration (biology) NF-κβ nuclear factor κβ IGF insulinlike growth factor PTU 6-n-propyl-2-thiouracil GH growth hormone IL interleukin InsP3 inositol 1 4 5-trisphosphate PI3K phosphatidylinositol-4 5-bisphosphate 3-kinase Cancer research TR thyroid receptor HGF hepatocyte growth factor LRP low-density lipoprotein-related protein business LDLT living donor liver transplant MAPK mitogen-activated protein kinase Transforming growth factor Hormone |
| Zdroj: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 4, Iss 3, Pp 315-338 (2020) Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| ISSN: | 2542-4548 |
| Popis: | An understanding of the molecular basis of liver regeneration will open new horizons for the development of novel therapies for chronic liver failure. Such therapies would solve the drawbacks associated with liver transplant, including the shortage of donor organs, long waitlist time, high medical costs, and lifelong use of immunosuppressive agents. Regeneration after partial hepatectomy has been studied in animal models, particularly fumarylacetoacetate hydrolase–deficient (FAH−/−) mice and pigs. The process of regeneration is distinctive, complex, and well coordinated, and it depends on the interplay among several signaling pathways (eg, nuclear factor κβ, Notch, Hippo), cytokines (eg, tumor necrosis factor α, interleukin 6), and growth factors (eg, hepatocyte growth factor, epidermal growth factor, vascular endothelial growth factor), and other components. Furthermore, endocrinal hormones (eg, norepinephrine, growth hormone, insulin, thyroid hormones) also can influence the aforementioned pathways and factors. We believe that these endocrinal hormones are important hepatic mitogens that strongly induce and accelerate hepatocyte proliferation (regeneration) by directly and indirectly triggering the activity of the involved signaling pathways, cytokines, growth factors, and transcription factors. The subsequent induction of cyclins and associated cyclin-dependent kinase complexes allow hepatocytes to enter the cell cycle. In this review article, we comprehensively summarize the current knowledge regarding the roles and mechanisms of these hormones in liver regeneration. Articles used for this review were identified by searching MEDLINE and EMBASE databases from inception through June 1, 2019. |
| Databáze: | OpenAIRE |
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