Pseudocholinesterase Deficiency Considerations: A Case Study
| Autor: | Todd M. Jacobs, Bryant W. Cornelius |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Apnea
business.industry Succinylcholine Signs and symptoms 030204 cardiovascular system & hematology medicine.disease Bioinformatics BUTYRYLCHOLINESTERASE DEFICIENCY Pathophysiology Mivacurium 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine Continuing Education in Memory of Norman Trieger Dmd Md Butyrylcholinesterase Pseudocholinesterase deficiency medicine Humans Female 030212 general & internal medicine business Metabolism Inborn Errors |
| Zdroj: | Anesth Prog |
| ISSN: | 1878-7177 0003-3006 |
| DOI: | 10.2344/anpr-67-03-16 |
| Popis: | Pseudocholinesterase deficiency, sometimes called butyrylcholinesterase deficiency, is a rare disorder in which the neuromuscular blocking drugs succinylcholine and mivacurium cannot be metabolized properly in the blood plasma. This disorder can either be acquired as a result of certain comorbidities or it can be inherited genetically. Anesthesia providers must understand the pathophysiology of pseudocholinesterase deficiency and be prepared to safely and effectively manage patients who show signs and symptoms consistent with the disorder after the use of the indicated neuromuscular blocking drugs. This article summarizes the pharmacologic and physiologic data relevant to understanding the basic pathophysiology associated with pseudocholinesterase deficiency and illustrates a case study of a young woman suspected of having the disorder after a prolonged delay in emergence from general anesthesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|