The Role of miR-129-5p in Cancer: A Novel Therapeutic Target

Autor: Wei Li, Shan Xu, Yanlan Li, Jing Wu, Hui Ling, Ming Xie, Tiebing Zeng, Yuru Lu, Juan Zou
Rok vydání: 2022
Předmět:
Zdroj: Current Molecular Pharmacology. 15:647-657
ISSN: 1874-4672
Popis: Abstract: miRNA-129-5p belongs to the microRNA-129 (miRNA-129) family. miRNA-129-5p is expressed in many tissues and organs of the human body, and it regulates a wide range of biological functions. The abnormal expression of miRNA-129-5p is related to the occurrence and development of a variety of malignant tumors. miRNA-129-5p plays an important role in the tumorigenesis process and functions by promoting or inhibiting tumors. However, the role of miRNA-129-5p in cancer remains controversial. This article reviews the different biological functions of miRNA- 129-5p in cancer and provides ideas for research in this field to guide the development of targeted therapies and drugs for malignant tumors.
Databáze: OpenAIRE