Haloperidol treatment increases D2 dopamine receptor protein independently of RNA levels in mice
| Autor: | Andrea B. Kelly, James R. Goss, David G. Morgan, Steven A. Johnson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Transcription Genetic Mice Inbred Strains Pharmacology General Biochemistry Genetics and Molecular Biology Receptors Dopamine Mice Dopamine receptor D1 Internal medicine Dopamine receptor D2 Gene expression medicine Haloperidol Animals RNA Messenger General Pharmacology Toxicology and Pharmaceutics Chemistry RNA General Medicine Blotting Northern Up-Regulation Endocrinology Mechanism of action Gene Expression Regulation Dopamine receptor Nucleic acid medicine.symptom medicine.drug |
| Zdroj: | Life sciences. 48(10) |
| ISSN: | 0024-3205 |
| Popis: | Haloperidol, administered to mice in their drinking water, produced a 21% increase in striatal D2 dopamine receptor density after seven days of continuous exposure. The steady-state D2 receptor RNA prevalence was unaffected by this treatment, yet the RNA coding for preproenkephalin was elevated, as expected. These data indicate that the homologous up-regulation of dopamine receptor density by antipsychotic drugs proceeds by mechanisms other than changes in RNA abundance. |
| Databáze: | OpenAIRE |
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