Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
| Autor: | K. Lapis, A. Zalatnai |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Time Factors Cirrhosis CCL4 Liver Cirrhosis Experimental digestive system chemistry.chemical_compound Liver Neoplasms Experimental Internal medicine parasitic diseases medicine Animals Diethylnitrosamine Carbon Tetrachloride Carcinogen Carbon Tetrachloride Poisoning Chemistry medicine.disease Rats Inbred F344 digestive system diseases Rats Endocrinology Liver Oncology Nitrosamine Phenobarbital Carbon tetrachloride Precancerous Conditions medicine.drug |
| Zdroj: | Cancer Letters. 79:1-7 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(94)90055-8 |
| Popis: | The relationship between CCl4 or (CCl4 + phenobarbital)-induced liver cirrhosis and diethylnitrosamine (DEN) hepatocarcinogenesis in male F-344 rats was investigated. DEN given alone produced no liver lesions after 16 weeks, but 4 12 (33%) neoplastic nodules developed when nitrosamine was administered to rats with previously established cirrhosis. On the other hand, (CCl4 + phenobarbital) post-treatment had an even stronger effect, increasing the yield of neoplastic nodules to 100% ( 28 28 ). Since the exposure time of DEN was the same in all treated groups (4 months), the results indicate the decreased effectiveness of (CCl4 + phenobarbital) pretreatment on DEN hepatocarcinogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|