Influence of age and sex on serum concentrations of total dimeric activin A
| Autor: | Carlo Foresta, Chiarina Grisolia, Annibale Volpe, Paola Loria, P. Martella, Marco Bertolotti, Stefano Luisi, Nicola Carulli, M. Concari, Andrea R. Genazzani, Felice Petraglia |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject Biology Follicle-stimulating hormone Endocrinology Pregnancy Internal medicine Blood plasma medicine Humans Inhibins Growth Substances Menstrual cycle Aged media_common Aged 80 and over Sex Characteristics General Medicine Middle Aged medicine.disease Activins Cohort activin A Female Follicle Stimulating Hormone Gonadotropin hormones hormone substitutes and hormone antagonists Hormone Sex characteristics |
| Zdroj: | Scopus-Elsevier |
| Popis: | Several studies have shown that activin A is secreted in substantial amounts into the systemic circulation. The changes that occur during menstrual cycle and pregnancy suggest a correlation with reproductive function. At present, however, no definitive evidence has confirmed this pattern throughout adult life; moreover, neither the origin nor the physiological implications of this circulating growth factor have been clearly defined. The aim of the present study was to evaluate whether circulating concentrations of activin A change in adult men and women according to age and sex, and to examine the possible correlation with serum concentrations of FSH. Total dimeric activin A was measured using a specific two-site enzyme immunoassay in serum specimens collected from a cohort of normal individuals enrolled in an epidemiological survey. A group of men (n = 106) and one of women (n=151) were subdivided into six age groups (20-30, 30-40, 40-50, 50-60, 60-70 and 70-90 years). In a small group of 8 men and 11 women, serum concentrations of activin A were evaluated twice, in specimens collected at an interval of 10 years. Serum FSH concentrations were also measured in all specimens. Serum concentrations of activin A were not significantly different in men and women and showed an age-related progressive increase between 20 and 50 years of age (P |
| Databáze: | OpenAIRE |
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