| Autor: |
Abigail K. Kois, Jason A. Gluck, David P. Nicolau, Joseph L. Kuti |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Antimicrobial Agents. 60:106603 |
| ISSN: |
0924-8579 |
| DOI: |
10.1016/j.ijantimicag.2022.106603 |
| Popis: |
This study determined the pharmacokinetics of cefepime in patients requiring extracorporeal membrane oxygenation (ECMO) support to guide dosage selection. Cefepime population pharmacokinetics where characterized in Pmetrics for R for six critically ill patients receiving ECMO. Simulation was employed to determine the fTMIC and total trough concentration of varying regimens in each patient to evaluate ability to achieve optimal pharmacodynamic exposure and thresholds for cefepime-associated neurotoxicity. Of the six participants, two required continuous veno-venous hemodiafiltration (CVVHDF) while four had a CrCL between 92-199 ml/min. All patients received 2 g q8h as a 3h infusion. A two-compartment model fitted the data best with median (range) parameter estimates as follows: clearance, 5.99 (4.10-10.29) L/h; volume of central compartment, 10.08 (2.45-15.14) L; and intercompartment transfer constants (k |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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