A Novel Method to Detect and Monitor Retinal Vasculitis Using Swept-Source OCT Angiography
| Autor: | Janet L. Davis, Jin Yang, Yingying Shi, Thomas A. Albini, Giovanni Gregori, Philip J. Rosenfeld, Jila Noori |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fovea Centralis
medicine.medical_specialty Retinal thickening Fundus Oculi Population Visual Acuity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oct angiography Ophthalmology medicine Humans Fluorescein Angiography education Retrospective Studies 030304 developmental biology Retinal Vasculitis 0303 health sciences education.field_of_study Retina medicine.diagnostic_test Retinal vasculitis business.industry Retinal Vessels Retinal medicine.disease Fluorescein angiography medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Vasculitis business Tomography Optical Coherence |
| Zdroj: | Ophthalmology Retina. 5:1226-1234 |
| ISSN: | 2468-6530 |
| DOI: | 10.1016/j.oret.2021.02.007 |
| Popis: | Purpose To introduce a novel method for assessment of retinal vasculitis using swept-source OCT angiography (SS-OCTA). Design Retrospective case series. Participants Patients with retinal vasculitis. Methods The subjects were identified among the clinic population and imaged with 12 × 12-mm SS-OCTA scans centered on the fovea. A custom retina segmentation superimposed the color retinal thickness map on a modified en face flow scan. Findings from en face flow scans were correlated with localized perivascular retinal thickening on B-scans. Results from SS-OCTA were compared with fluorescein angiography (FA) to examine the proportion of perivascular thickening to retinal vascular leakage or staining. Results Twenty-one patients with retinal vasculitis underwent same-day FA and SS-OCTA. Visible retinal vascular leakage/staining on FA corresponded to increased perivascular retinal thickness on SS-OCTA in 17 patients. Five patients had a second examination with same-day FA and SS-OCTA after treatment of the vasculitis. Three of those 5 patients showed improved retinal vascular leakage/staining on post-treatment FA and decreased perivascular retinal thickness on SS-OCTA scans. Conclusions Swept-source OCT angiography detects structural retinal thickening secondary to inflammatory retinal vascular leakage. Further studies are required to confirm whether SS-OCTA may serve as a semiquantitative alternative to FA to diagnose and monitor the response to treatment in patients with retinal vasculitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|