The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis
| Autor: | Putu Nina Berlinda Saka, Budi Susetio Pikir, Rizal Rahmanda Akbar, Teuku Heriansyah, Erdo Puncak Sidarta, Jonny Karunia Fajar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
RD1-811 Review Article 030204 cardiovascular system & hematology Peptidyl-Dipeptidase A Left ventricular hypertrophy 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype medicine Diseases of the circulatory (Cardiovascular) system Humans 030212 general & internal medicine Allele Gene Sequence Deletion Polymorphism Genetic biology business.industry Intron ACE G2350A Angiotensin-converting enzyme medicine.disease Introns ACE I/D Endocrinology RC666-701 Meta-analysis biology.protein Surgery Hypertrophy Left Ventricular Gene polymorphism Cardiology and Cardiovascular Medicine business |
| Zdroj: | Indian Heart Journal Indian Heart Journal, Vol 71, Iss 3, Pp 199-206 (2019) |
| ISSN: | 2213-3763 |
| Popis: | Objectives: The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Methods: Information related to the sample size and genotype frequencies was extracted from each study. Results: Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Conclusions: Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy. Keywords: Left ventricular hypertrophy, Angiotensin-converting enzyme, ACE I/D, ACE G2350A |
| Databáze: | OpenAIRE |
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