Vestibular Impairment in Frontotemporal Dementia Syndrome
| Autor: | Satoshi Aizawa, Kiyotaka Nakamagoe, Naoki Tozaka, Mao Takiguchi, Fumiko Yamamoto, Tetsuya Moriyama, Seitaro Nohara, Zenshi Miyake, Kumi Yanagiha, Akira Tamaoka, Kotarou Kadono, Makoto Terada, Tadachika Koganezawa, Kentaro Furusho |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Cognitive Neuroscience Audiology Caloric test lcsh:Geriatrics Frontotemporal lobar degeneration VESTIBULAR IMPAIRMENT lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine mental disorders medicine otorhinolaryngologic diseases Original Research Article Vestibular function Visual suppression lcsh:Neurology. Diseases of the nervous system Vestibular system business.industry nutritional and metabolic diseases Inferior parietal lobule Vestibular stimulation medicine.disease nervous system diseases Psychiatry and Mental health lcsh:RC952-954.6 030104 developmental biology Visual Suppression business Frontal eye field 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Dementia and Geriatric Cognitive Disorders Extra, Vol 6, Iss 2, Pp 194-204 (2016) Dementia and Geriatric Cognitive Disorders EXTRA |
| ISSN: | 1664-5464 |
| Popis: | Background: No studies to date have attempted to evaluate frontotemporal lobar degeneration from the perspective of the vestibular system. Objective: The present study examined vestibular function in patients with frontotemporal dementia (FTD) clinical syndrome and evaluated whether vestibular disorders are involved in the clinical symptoms due to FTD. Methods: Fourteen patients with FTD syndrome, as well as healthy elderly controls without dementia, were included in the present study. All subjects underwent vestibular function tests using electronystagmography, such as caloric tests and visual suppression (VS) tests, in which the induced caloric nystagmus was suppressed by visual stimuli. The association between clinical symptoms and vestibular function in the FTD syndrome group was further examined. Results: In the FTD syndrome group, caloric nystagmus was not necessarily suppressed during VS tests. Furthermore, VS was observed to be significantly impaired in FTD syndrome patients with gait disturbance as compared to those without such disturbance. Conclusion: The present study revealed that impairment of VS in patients with FTD results in an inability to regulate vestibular function by means of visual perception, regardless of multiple presumed neuropathological backgrounds. This could also be associated with gait disturbance in patients with FTD syndrome. |
| Databáze: | OpenAIRE |
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