MRI quantifies lumbosacral nerve root and sciatic nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy
| Autor: | Mary M. Reilly, Jasper M. Morrow, Christopher D. J. Sinclair, John S. Thornton, Sachit Shah, Michael P. Lunn, Tarek A. Yousry |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Nerve root Lumbosacral Plexus 030218 nuclear medicine & medical imaging Muscle hypertrophy Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging In patient Prospective Studies Aged medicine.diagnostic_test business.industry Magnetic resonance imaging Polyradiculoneuropathy Hypertrophy General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Sciatic Nerve Lumbosacral plexus Polyradiculoneuropathy Chronic Inflammatory Demyelinating ROC Curve 030220 oncology & carcinogenesis Female Sciatic nerve business Lumbosacral joint |
| Zdroj: | European Journal of Radiology. 130:109164 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2020.109164 |
| Popis: | Purpose Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a treatable, immune-mediated condition characterised by progressive or relapsing motor and sensory neurological deficits. The diagnosis is based on a combination of clinical, neurophysiological and supportive criteria, but can be challenging. In this study, we quantified the diameter and cross-sectional area of the lumbosacral nerve roots, and explored the imaging characteristics of the sciatic nerves, in patients with CIDP versus healthy controls using MRI. Methods MRI of the lumbosacral plexus and both thighs was performed at 3 T. Orthogonal diameter and cross-sectional area of the lumbosacral nerve roots were measured, along with sciatic nerve cross-sectional area at the mid-thigh level. The MRI appearance of the sciatic nerves was also evaluated qualitatively. All measurements were performed by an observer blinded to the diagnosis. Results 10 patients with CIDP and 10 healthy controls (age and sex-matched) were studied. Lumbosacral nerve root diameter and cross-sectional area were significantly increased in patients with CIDP compared to controls (mean diameter 6.0 ± 1.1 mm vs 4.8 ± 0.3 mm; p = 0.006), with a high sensitivity (89 %) and specificity (90 %) on ROC analysis. Sciatic nerve cross sectional area was also significantly increased in the CIDP group, and was accompanied by qualitative MRI changes. Conclusions Quantitative MRI reveals significant hypertrophy of the lumbosacral nerve roots and sciatic nerves in patients with CIDP compared to controls. This study provides further evidence for the inclusion of lumbosacral nerve root and sciatic nerve hypertrophy on MRI as a supportive feature in the diagnostic criteria for CIDP. |
| Databáze: | OpenAIRE |
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