HaemoPREF: Further evaluation of patient perception and preference for treatment in a real world setting
| Autor: | E. Brohan, Ana C Gordo, Michael Cicchetti, Dean Spurden, Joseph C. Cappelleri, H. Staunton, Santiago Bonanad, Martin Schulz, Chloe Tolley |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate statistics Haemophilia Patients Psychometrics Intraclass correlation 030204 cardiovascular system & hematology Hemophilia A Spearman's rank correlation coefficient Preference Correlation 03 medical and health sciences 0302 clinical medicine Cronbach's alpha Patient-Reported Outcome HaemoPREF Germany Surveys and Questionnaires medicine Humans Genetics (clinical) Aged Factor VIII business.industry Ease of Use Reproducibility of Results Patient Preference Hematology General Medicine Middle Aged medicine.disease Treatment Adherence and Compliance Cross-Sectional Studies Convergent validity Italy Patient Satisfaction Spain Physical therapy Treatment Satisfaction Patient-reported outcome Perception business 030215 immunology |
| Zdroj: | HAEMOPHILIA r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1351-8216 |
| Popis: | IntroductionAdherence to haemophilia A (HA) treatment may be influenced by patients' beliefs about their condition and treatment. Furthermore, difficulties administering treatment may lead to poor adherence. New treatment strategies aim to reduce the burden associated with administration and to improve patient perception of treatment, which, in turn, increase adherence levels. AimsThis study aimed to examine patient perception of HA treatment and related factors using patient-reported outcome (PRO) questionnaires and to confirm the psychometric properties of a recently developed questionnaire, the HaemoPREF. MethodsA non-interventional, cross-sectional, questionnaire study was conducted with adult HA patients in Spain (n=31), Germany (n=10) and Italy (n=48), who were using ReFacto AF with the FuseNGo administration device. Patients completed the HaemoPREF and other questionnaires measuring related constructs: treatment adherence, satisfaction and well-being, online at two time points. Correlational, regression and psychometric analyses were conducted. ResultsPRO scores indicated that patients are satisfied with and adherent to their treatment. Multivariate regression of the HaemoPREF global score identified a number of significant predictors (P.05). The HaemoPREF Global Score had a moderate relationship with subscales on the related questionnaires (mean correlation=0.43; range=0.39-0.48). The HaemoPREF demonstrated good test-retest reliability (intraclass correlation coefficient=0.82), internal consistency reliability (Cronbach's alpha range=0.69-0.82) and convergent validity with measures of treatment satisfaction (Spearman correlation coefficient, r=.48) and well-being (r=.41). ConclusionThe findings suggest that patients using ReFacto AF with FuseNGo were satisfied with and adherent to their treatment. The HaemoPREF can identify important concepts relating to patient treatment experience in HA. |
| Databáze: | OpenAIRE |
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