Presence of Simian Virus 40 DNA Sequences in Human Lymphoid and Hematopoietic Malignancies and Their Relationship to Aberrant Promoter Methylation of Multiple Genes
| Autor: | Steven H. Kroft, Yingye Zheng, Charles F. Timmons, Narayan Shivapurkar, Adi F. Gazdar, Gunjan Parikh, Sheryl L. Asplund, Makato Suzuki, Robert W. McKenna, Ziding Feng, Robert H. Collins, Takao Takahashi, Victor Stastny, Jyotsna Reddy, Shinichi Toyooka |
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| Rok vydání: | 2004 |
| Předmět: |
Herpesvirus 4
Human Cancer Research viruses Simian virus 40 Biology Virus CDH1 hemic and lymphatic diseases medicine Humans Gene silencing Promoter Regions Genetic Leukemia Lymphoma Non-Hodgkin Methylation DNA Methylation medicine.disease Virology Lymphoma Oncology CpG site DNA Viral DNA methylation Leukocytes Mononuclear Cancer research biology.protein Oncovirus |
| Zdroj: | Cancer Research. 64:3757-3760 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-03-3307 |
| Popis: | The simian polyoma virus SV40 has been detected in specific human tumors including non-Hodgkin’s lymphomas, although a causative role for the virus has not been convincingly demonstrated. Aberrant methylation of CpG islands in promoter regions is a frequent method of silencing tumor suppressor genes (TSGs) in cancers and may be induced by oncogenic viruses. We investigated the relationship between the presence of SV40 or EBV DNA sequences and the methylation profiles for 10 TSGs in 90 cases of non-Hodgkin’s lymphomas/leukemias and 56 control tissues. SV40 sequences were present in 33/90 (37%) non-Hodgkin’s lymphomas/leukemias, and EBV was present in 11/42 (26%) of non-Hodgkin’s lymphomas. We found a highly significant correlation between the presence of SV40 and methylation of seven genes (P values, 0.006 to |
| Databáze: | OpenAIRE |
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