Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients

Autor: Yury Gerasimenko, Yevgeniy Freyvert, Erika Morikawa, V. Reggie Edgerton, Daniel C. Lu, Sharon Zdunowski, Melanie E. Sarino, Nicholas Au Yong
Rok vydání: 2018
Předmět:
Male
030506 rehabilitation
lcsh:Medicine
Stimulation
Neurodegenerative
Neck Injuries
Grip strength
0302 clinical medicine
Injury - Trauma - (Head and Spine)
Paralysis
lcsh:Science
Spinal Cord Injury
Evoked Potentials
Multidisciplinary
Hand Strength
Rehabilitation
Combined Modality Therapy
Buspirone
3. Good health
Serotonin Receptor Agonists
medicine.anatomical_structure
Motor
Neurological
Upper limb
Female
Analysis of variance
medicine.symptom
0305 other medical science
medicine.drug
Adult
medicine.medical_specialty
Adolescent
Movement
Electric Stimulation Therapy
Article
03 medical and health sciences
Young Adult
Physical medicine and rehabilitation
Clinical Research
Hand strength
medicine
Humans
Spinal Cord Injuries
business.industry
lcsh:R
Neurosciences
Repeated measures design
Recovery of Function
Evoked Potentials
Motor
Hand
Injury (total) Accidents/Adverse Effects
lcsh:Q
business
030217 neurology & neurosurgery
Zdroj: Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Popis: The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated through measures of controlled hand contraction, handgrip force production, dexterity measures, and validated clinical assessment batteries. Repeated measure analysis of variance was used to evaluate functional metrics, EMG amplitude, and changes in mean grip strength. In aggregate, mean hand strength increased by greater than 300% with transcutaneous electrical stimulation and buspirone while a corresponding clinically significant improvement was observed in upper extremity motor scores and the action research arm test. Some functional improvements persisted for an extended period after the study interventions were discontinued. We demonstrate that, with these novel interventions, cervical spinal circuitry can be neuromodulated to improve volitional control of hand function in tetraplegic subjects. The potential impact of these findings on individuals with upper limb paralysis could be dramatic functionally, psychologically, and economically.
Databáze: OpenAIRE
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