Comparative evaluation of cytokine and acute-phase protein concentrations in sera of dairy cows with subclinical and clinical ketosis as a different view of the causes of the disease
| Autor: | Marek Szczubiał, Jan Marczuk, Urszula Lisiecka, Piotr Brodzki, Katarzyna Kulpa, Adam Brodzki, Hubert Gorzkoś |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
ketosis 040301 veterinary sciences Veterinary medicine Systemic inflammation SF1-1100 0403 veterinary science Blood serum Internal medicine SF600-1100 cytokine Medicine dairy cows Serum amyloid A Interleukin 6 Subclinical infection General Veterinary biology business.industry Haptoglobin 0402 animal and dairy science Acute-phase protein food and beverages 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science Animal culture Endocrinology acute-phase proteins biology.protein Ketosis medicine.symptom business Research Article |
| Zdroj: | Veterinary World, Vol 14, Iss 6, Pp 1572-1578 (2021) Veterinary World |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Background and Aim: Ketosis is a common disease occurring during the first stage of lactation in highly productive dairy cows. The aim of the present study was the comparative assessment of selected pro-inflammatory cytokines (including tumor necrosis factor-α [TNF-α] and interleukin 6 [IL-6]), anti-inflammatory cytokines (including IL-10), and acute-phase proteins (APPs) (including haptoglobin [Hp] and serum amyloid A [SAA]), in the sera of cows with subclinical ketosis (SCK), in those with clinical ketosis (CK), and in healthy cows. Materials and Methods: Thirty dairy cows of Holstein-Friesian breed were investigated. The cows were divided into three groups depending on the serum β-hydroxybutyric acid (BHBA) level. The control, SCK, and CK groups included healthy cows, cows with SCK, and cows with CK, respectively. BHBA concentration in blood serum was determined using colorimetric method. The blood serum was used for proper tests. Cytokine (TNF-α, IL-6, and IL-10) and APPs (SAA and Hp) concentrations in the investigated samples were determined by enzyme-linked immunosorbent assay method. Results: The SCK group had significantly higher TNF-α, IL-6; IL-10, and SAA values than had the CK group (p |
| Databáze: | OpenAIRE |
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