Pregnancy and Renal Transplantation: A Case Report of the Risk of Antibody Induction Against Partner Antigens
| Autor: | Elisa Lazzarich, R. Fenoglio, D.M. Paternoster, C. Cornella, R. Conca, L. Praticò, Nicola Surico, F. Riboni |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Graft Rejection Isoantigens Pediatrics medicine.medical_specialty medicine.medical_treatment Intrauterine growth restriction HLA Antigens Isoantibodies Pregnancy Reference Values Cadaver medicine Humans Kidney transplantation Transplantation Kidney business.industry Histocompatibility Testing Immunosuppression medicine.disease Kidney Transplantation Tissue Donors Pregnancy Complications Low birth weight medicine.anatomical_structure Creatinine Immunology Kidney Failure Chronic Gestation Drug Therapy Combination Female Surgery medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Transplantation Proceedings. 41:3964-3966 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2009.06.233 |
| Popis: | Renal transplantation has provided women of childbearing age with increased fertility and the possibility of successful pregnancy outcomes. Approximately 14,000 births among women with transplanted organs have been reported worldwide, but pregnancy complications have been frequent: spontaneous or therapeutic abortion, preterm birth, low birth weight, and intrauterine growth restriction. Herein we have described a case of an acute rejection episode in a renal transplant recipient, occurring 6 months after successful delivery, despite the fulfillment of all European best practice guidelines criteria and the maintenance of adequate immunosuppression. Our case demonstrated that even a presumably low-risk patient can face worsening of renal function during or after pregnancy. Acute immune activation is uncommon but may occur in late-onset fashion. Despite adequate levels of maintenance immunosuppression, there is a risk of developing antibodies against the partner or the donor, causing acute renal immune damage. |
| Databáze: | OpenAIRE |
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