Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients
Autor: | George D. Vavougios, Konstantinos T. Ntoskas, Triantafyllos Doskas |
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Rok vydání: | 2021 |
Předmět: |
Platelets
Blood Platelets 0301 basic medicine Endothelium Critical Illness Bioinformatics Article Transcriptome Selenium 03 medical and health sciences 0302 clinical medicine Immune system Coagulopathy medicine Homeostasis Humans Platelet Platelet activation Inflammation SARS-CoV-2 business.industry COVID-19 General Medicine Blood Coagulation Disorders Models Theoretical Platelet Activation medicine.disease Selenocysteine Oxidative Stress 030104 developmental biology medicine.anatomical_structure Immune System Endothelium Vascular business 030217 neurology & neurosurgery Intracellular |
Zdroj: | Medical Hypotheses |
ISSN: | 0306-9877 |
DOI: | 10.1016/j.mehy.2020.110475 |
Popis: | Coagulopathy has recently been recognized as a recurring complication of COVID-19, most typically associated with critical illness. There are epidemiological, mechanistic and transcriptomic evidence that link Selenium with SARS-CoV-2's intracellular latency. Taking into consideration the vital role of selenoproteins in maintaining an adequate immune response, endothelial homeostasis and a non-prothrombotic platelet activation status, we propose that impairment in selenocysteine synthesis, via perturbations in the aforementioned physiological functions, potentially constitutes a mechanism of coagulopathy in COVID 19 patients other than those developed in critical illness. |
Databáze: | OpenAIRE |
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