Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients

Autor: George D. Vavougios, Konstantinos T. Ntoskas, Triantafyllos Doskas
Rok vydání: 2021
Předmět:
Zdroj: Medical Hypotheses
ISSN: 0306-9877
DOI: 10.1016/j.mehy.2020.110475
Popis: Coagulopathy has recently been recognized as a recurring complication of COVID-19, most typically associated with critical illness. There are epidemiological, mechanistic and transcriptomic evidence that link Selenium with SARS-CoV-2's intracellular latency. Taking into consideration the vital role of selenoproteins in maintaining an adequate immune response, endothelial homeostasis and a non-prothrombotic platelet activation status, we propose that impairment in selenocysteine synthesis, via perturbations in the aforementioned physiological functions, potentially constitutes a mechanism of coagulopathy in COVID 19 patients other than those developed in critical illness.
Databáze: OpenAIRE