Neonatal platelets from cord blood and peripheral blood
| Autor: | Christian P. Speer, D. Singer, Ulrich Walter, A. Obergfell, S. Holzhauer, Ana Gabriela Sitaru, Ralf Grossmann |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Platelets medicine.medical_specialty P-selectin Acid Phosphatase Gestational Age Platelet Glycoprotein GPIIb-IIIa Complex Platelet Membrane Glycoproteins Platelet membrane glycoprotein Cell Degranulation Internal medicine medicine Humans Platelet Protein Phosphatase 2 Mean platelet volume Whole blood Blood Cells Tartrate-Resistant Acid Phosphatase business.industry Infant Newborn Dual Specificity Phosphatase 2 Gestational age Hematology General Medicine Fetal Blood Flow Cytometry Isoenzymes P-Selectin Endocrinology Cord blood Immunology Premature Birth Gestation Protein Tyrosine Phosphatases business |
| Zdroj: | Platelets. 16:203-210 |
| ISSN: | 1369-1635 0953-7104 |
| Popis: | The haemostatic system in neonates is different from that of adults, possibly contributing to an increased incidence of bleeding disorders, such as intracranial hemorrhage. In this study, we analyzed platelets from cord blood and peripheral blood, collected at three time points after delivery from 20 term and 37 preterm neonates as well as blood from 20 healthy adults. Platelet membrane glycoproteins (GP) were quantified and P-selectin expression and PAC-1 binding ability before and after stimulation with TRAP were analyzed by whole blood flow cytometry. We found no significant differences in neonatal platelets from cord blood and peripheral blood within the first 24h of life. Platelets from infants less than 30 weeks of gestation expressed lower levels of GP (33271+/-9381 vs. 44085+/-17287 for GPIIIa, P |
| Databáze: | OpenAIRE |
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