Induced Accumulation of Citrate in Therapy of Experimental Lead Poisoning
| Autor: | Marcia W. Rosenthal, Jack Schubert, Joan F. Fried |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
medicine.medical_treatment
Metal toxicity Pharmacology Lead nitrate medicine.disease Citric Acid General Biochemistry Genetics and Molecular Biology Lead poisoning Lead Poisoning chemistry.chemical_compound chemistry Biochemistry Toxicity medicine Humans Citrates Citric acid Saline Sodium fluoroacetate |
| Zdroj: | Experimental Biology and Medicine. 92:331-333 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-92-22468 |
| Popis: | SummaryThe concept of interference in a metabolic cycle as a means of modifying metal toxicity has been tested. The accumulation of citric acid in certain soft tissues of the rat has been induced by administration of small, non-lethal doses of sodium fluoroacetate. This has been found to give partial protection to rats acutely poisoned with lead nitrate. Of rats given the LD90 of lead nitrate, 53% survived when treated with sodium fluoroacetate. The LD50 of lead nitrate was increased from 58.2 mg/kg (as Pb) in saline controls to 67.7 mg/kg in fluoroacetate-treated rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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