Membrane Morphology Modifications Induced by Hydroquinones
| Autor: | Liliana Marzorati, Sérgio S. Funari, Claudio Di Vitta, Vivian Rebbin |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular Morphology (linguistics) Surface Properties Stereochemistry Lipid Bilayers chemistry [Lipid Bilayers] chemistry [Hydroquinones] chemistry [Phosphatidylethanolamines] chemistry.chemical_compound ddc:670 Electrochemistry Molecule General Materials Science Lamellar structure Particle Size chemistry [Phosphatidylcholines] Lipid bilayer POPC 1-palmitoyl-2-oleoylphosphatidylcholine Spectroscopy chemical synthesis [Hydroquinones] Molecular Structure Phosphatidylethanolamines Bilayer Temperature Stereoisomerism Surfaces and Interfaces Hydrogen-Ion Concentration Condensed Matter Physics 1-palmitoyl-2-oleoylphosphatidylethanolamine Hydroquinones Membrane chemistry Chemical physics Phosphatidylcholines QUÍMICA ORGÂNICA Particle size |
| Zdroj: | Langmuir 27, 8257-8262 (2011). doi:10.1021/la200768x Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la200768x |
| Popis: | We synthesize and characterize alkylthiohydroquinones (ATHs) in order to investigate their interactions with lipid model membranes, POPE and POPC. We observe the formation of structures with different morphologies, or curvature of the lipid bilayer, depending on pH and increasing temperature. We attribute their formation to changes in the balance charge/polarity induced by the ATHs. Mixtures of ATHs with POPE at pH 4 form two cubic phases, P4(3)32 and Im3m, that reach a maximum lattice size at 40 °C while under basic conditions these phases only expand upon heating from room temperature. The cubic phases coexist with lamellar or hexagonal phases and are associated with inhomogeneous distribution of the ATH molecules over the lipid matrix. The zwitterionic POPC does not form cubic phases but instead shows lamellar structures with no clear influence of the 2,6-BATH. |
| Databáze: | OpenAIRE |
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