Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.)
| Autor: | D.H. Paper, Liselotte Krenn |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Angiogenesis
Pharmaceutical Science Genistein Angiogenesis Inhibitors Phytoestrogens Chick Embryo Pharmacology Biology Methylation Chorioallantoic Membrane Biochanin A chemistry.chemical_compound In vivo Drug Discovery Botany Animals Inflammation Plant Extracts Daidzein food and beverages Isoflavones Red Clover Chorioallantoic membrane Complementary and alternative medicine chemistry Molecular Medicine Trifolium |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 16(12) |
| ISSN: | 1618-095X |
| Popis: | Antiangiogenic compounds are gaining more and more interest as a new approach in the prevention and treatment of cancer and inflammatory diseases. The objective of this study was the evaluation of the antiangiogenic effect of a red clover extract (RCE) used in food supplements for menopausal complaints as well as of its main isoflavones in an in vivo system, the chorioallantoic membrane assay of fertilized hen's eggs. At a dosage of 250 microg/pellet the red clover extract showed excellent inhibition of angiogenesis. The antiangiogenic activity of the non-methylated isoflavones daidzein and genistein was higher than that of the methylated compounds formononentin and biochanin A. The results demonstrate that RCE is not only suitable for menopausal complaints, but might also be a powerful chemopreventive agent against chronic diseases e.g. which have a high incidence especially in elderly female. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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