Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater
| Autor: | Kaisa Palmu, Sirke Torkkell, Pekka Mäntsälä, Tero Kunnari, Juha Hakala, Kristiina Ylihonko |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Anthracycline
Stereochemistry Molecular Sequence Data Cyclase Streptomyces Fungal Proteins chemistry.chemical_compound Bacterial Proteins Pharmacology (medical) Amino Acid Sequence Cloning Molecular DNA Fungal Isomerases Streptomyces nogalater Pharmacology Fungal protein Antibiotics Antineoplastic Sequence Homology Amino Acid biology Streptomycetaceae Nogalamycin Stereoisomerism Chemistry Biosynthesis biology.organism_classification Culture Media Infectious Diseases Aglycone chemistry Biochemistry |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:396-399 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.44.2.396-399.2000 |
| Popis: | Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater . Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene sno aL, encoding a nogalonic acid methyl ester cyclase for nogalamycin, was used to generate nogalamycinone, demonstrating that the single cyclase dictates the C-9 stereochemistry of anthracyclines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|