Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target

Autor: Mariona Jové, Irene Pradas, Isidro Ferrer, Reinald Pamplona, Mayelin Dominguez-Gonzalez
Přispěvatelé: Universitat de Barcelona
Předmět:
0301 basic medicine
Aging
Clinical Biochemistry
Cell
Redox proteomics
medicine.disease_cause
Synaptic Transmission
Biochemistry
Antioxidants
Neurotransmissors
Adenosine Triphosphate
0302 clinical medicine
Citosquelet
lcsh:QH301-705.5
Cytoskeleton
Neurons
lcsh:R5-920
Brain
Human brain
Neurotransmitters
Mitochondrial Proton-Translocating ATPases
Lipids
Reactive carbonyl species
medicine.anatomical_structure
lcsh:Medicine (General)
Oxidation-Reduction
Metabolisme energètic
Estrès oxidatiu
Energy metabolism
Biology
03 medical and health sciences
Lipoxidation in pathophysiology and its assessment by high precision methodology
Envelliment
Lipidomics
medicine
Animals
Humans
Neurotransmission
Organic Chemistry
Mitochondrial ATP Synthase
Advanced lipoxidation end products
Lipid Metabolism
Oxidative Stress
030104 developmental biology
Proteostasis
lcsh:Biology (General)
Oxidative stress
Reactive Oxygen Species
Neuroscience
Biomarkers
030217 neurology & neurosurgery
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
Redox Biology, Vol 23, Iss, Pp-(2019)
Dipòsit Digital de la UB
Universidad de Barcelona
Redox Biology
Repositorio Abierto de la UdL
Universitad de Lleida
Popis: The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging. It is proposed that the restricted set of modified proteins and the functional categories involved may be considered putative collaborative factors contributing to neuronal aging, and that mitochondrial ATP synthase is a key lipoxidative target in human brain aging.
Graphical abstract fx1
Highlights • Human brain contains lipoxidized proteins, the levels of which vary among regions. • The ALEs-modified proteins increase in aged subjects. • Only 0.7% of the healthy aged brain proteome is lipoxidatively modified. • The selectivity of molecular damage is associated with specific structural traits. • Energy metabolism, neurotransmission, and cytoskeleton are the affected processes.
Databáze: OpenAIRE
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