Distribution of serotypes and evaluation of antimicrobial susceptibility among human and bovine Streptococcus agalactiae strains isolated in Brazil between 1980 and 2006
Autor: | Alexandre S. Rosado, I. Oliveira, Ligia Guedes Silva, Ana Beatriz de Almeida Corrêa, Aline R V Souza, Leslie C. Benchetrit, Tatiana C. A. Pinto, Marcos Corrêa de Mattos, Flavio Gimenis Fernandes, Natália S. Costa |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Microbiology (medical)
Adult Genotype medicine.drug_class Epidemiology Resistance profile lcsh:QR1-502 Erythromycin Microbial Sensitivity Tests Biology medicine.disease_cause lcsh:Microbiology Microbiology Macrolide Antibiotics lcsh:Infectious and parasitic diseases Streptococcus agalactiae chemistry.chemical_compound Pregnancy Drug Resistance Bacterial Pulsed-field gel electrophoresis medicine Animals Humans lcsh:RC109-216 Serotyping Child Medicine(all) Streptogramin B Clindamycin Genetic Variation Virology Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Penicillin Multiple drug resistance Infectious Diseases Phenotype Pulsed field gel electrophoresis chemistry Cattle Female Brazil medicine.drug |
Zdroj: | Brazilian Journal of Infectious Diseases v.17 n.2 2013 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 17, Iss 2, Pp 131-136 Brazilian Journal of Infectious Diseases, Vol 17, Iss 2, Pp 131-136 (2013) Brazilian Journal of Infectious Diseases, Volume: 17, Issue: 2, Pages: 131-136, Published: APR 2013 |
Popis: | Streptococcus agalactiae is a common agent of clinical and subclinical bovine mastitis and an important cause of human infections, mainly among pregnant women, neonates and nonpregnant adults with underlying diseases. The present study describes the genetic and phenotypic diversity among 392 S. agalactiae human and bovine strains isolated between 1980 and 2006 in Brazil. The most prevalent serotypes were Ia, II, III and V and all the strains were susceptible to penicillin, vancomycin and levofloxacin. Resistance to clindamycin, chloramphenicol, erythromycin, rifampicin and tetracycline was observed. Among the erythromycin resistant strains, mefA/E, ermA and, mainly, ermB gene were detected, and a shift of prevalence from the macrolide resistance phenotype to the macrolide-lincosamide-streptogramin B resistance phenotype over the years was observed. The 23 macrolide-resistant strains showed 19 different pulsed-field gel electrophoresis profiles. Regarding macrolide resistance, a major concern in S. agalactiae epidemiology, the present study describes an increase in erythromycin resistance from the 80s to the 90s followed by a decrease in the 2000–2006 period. Also, the genetic heterogeneity described points out that erythromycin resistance in Brazil is rather due to horizontal gene transmission than to spreading of specific macrolide-resistant clones. Keywords: Streptococcus agalactiae, Pulsed field gel electrophoresis, Epidemiology, Serotyping, Resistance profile |
Databáze: | OpenAIRE |
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