Administration of Human Chorionic Gonadotropin with a Controlled-Release Function to Immature Rats for Application in Male Infertility Therapy

Autor:	Kazuhiko Okabe, Hidetoshi Yamanaka, Yasuhiro Shibata, Hisako Yuasa, Masaharu Asano, Masaru Yoshida, Tooru Mashimo
Rok vydání:	2000
Předmět:	Male endocrine system medicine.medical_specialty medicine.drug_class Pharmaceutical Science Biology Testicle Chorionic Gonadotropin Human chorionic gonadotropin Seminal vesicle Internal medicine Absorbable Implants Testis Drug Discovery medicine Animals Testosterone Rats Wistar Infertility Male Pharmacology Leydig cell Organic Chemistry Immunohistochemistry Controlled release Rats Disease Models Animal medicine.anatomical_structure Endocrinology Delayed-Action Preparations Liberation Gonadotropin
Zdroj:	Drug Development and Industrial Pharmacy. 26:559-562
ISSN:	1520-5762 0363-9045
Popis:	Biodegradable poly(DL-lactic acid) (PLA) devices with controlled release of human chorionic gonadotropin (hCG) were fabricated in a 2-mm cylinder form by the melt-pressing technique. The devices fabricated were inserted subcutaneously in the backs of immature rats. It was found that the serum level of testosterone (T) remained constant at approximately 0.7 ng/ml for an experimental period of 14 days, resulting in greater Leydig cell production of testosterone. This was also suggested from the results of immunohistochemical observation of the testis and weight changes of prostates, such as the ventral prostates and seminal vesicle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5614edf8de454f69bf5d491741b574c https://doi.org/10.1081/ddc-100101268 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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