Frequency of Allopurinol Dose Reduction in Hospitalized Patients With Gout Flares
| Autor: | Jean W. Liew, Alison M. Bays, Irvin J Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Gout Hospitalized patients Allopurinol Immunology Population Hyperuricemia Gout Suppressants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Internal medicine medicine Humans Immunology and Allergy 030212 general & internal medicine Risk factor education 030203 arthritis & rheumatology education.field_of_study Drug Tapering business.industry Symptom Flare Up medicine.disease Discontinuation chemistry Cohort Uric acid business medicine.drug |
| Zdroj: | The Journal of Rheumatology. 48:467-468 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.201142 |
| Popis: | To the Editor: The risk of subsequent flares after the initial diagnosis of gout remains high, according to the recent study, “Changes in the Presentation of Incident Gout and the Risk of Subsequent Flares: A Population-based Study Over 20 Years” by Elfishawi, et al 1. This study found 60% of the patients have at least 1 subsequent flare episode within 5 years of their initial gout diagnosis. Despite an improved understanding of gout pathophysiology and treatment options, the prevalence of subsequent flares in the 2009–2010 cohort has not significantly improved compared to the 1989–1992 cohort. One of the identified risk factors was the persistently elevated serum uric acid (SUA). This finding highlights the importance of adequately treating gout to their target SUA. Limitations in their dataset may have precluded the authors from studying urate-lowering therapy (ULT) changes or discontinuation as a risk factor for subsequent flare. We report the results of our study below, in which we evaluated the frequency of inpatient adjustment of ULT in hospitalized … Address correspondence to Dr. I.J. Huang, 1959 NE Pacific St., BB561, Seattle, WA 98195, USA. Email: ijhuang{at}uw.edu. |
| Databáze: | OpenAIRE |
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