Impaired Right and Left Ventricular Longitudinal Function in Patients with Fibrotic Interstitial Lung Diseases
| Autor: | Ciro Santoro, Alessandro Sanduzzi, Agostino Buonauro, Roberta Esposito, Marialuisa Bocchino, Valeria Fazio, Federica Ilardi, Bruno Golia, Maurizio Galderisi, Maria Lembo, Mario Enrico Canonico, Regina Sorrentino, Angelo Canora |
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| Přispěvatelé: | Buonauro, Agostino, Santoro, Ciro, Galderisi, Maurizio, Canora, Angelo, Sorrentino, Regina, Esposito, Roberta, Lembo, Maria, Canonico, Mario Enrico, Ilardi, Federica, Fazio, Valeria, Golia, Bruno, Sanduzzi, Alessandro, Bocchino, Marialuisa |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population lcsh:Medicine Heart failure 030204 cardiovascular system & hematology Article Pulmonary hypertension 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Internal medicine 0502 economics and business Pulmonary fibrosis Diagnosis medicine education Lung diseases education.field_of_study Lung Ejection fraction business.industry lcsh:R 05 social sciences General Medicine respiratory system medicine.disease humanities Pulmonary embolism respiratory tract diseases medicine.anatomical_structure Echocardiography Lung disease Cardiology 050211 marketing business Diagnosi |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 2, p 587 (2020) Volume 9 Issue 2 |
| ISSN: | 2077-0383 |
| Popis: | Background: Left ventricular (LV) and right ventricular (RV) dysfunction is recognized in idiopathic pulmonary fibrosis (IPF). Little is known about cardiac involvement in non-idiopathic pulmonary fibrosis (no-IPF). This issue can be explored by advanced echocardiography. Methods: Thirty-three clinically stable and therapy-naive fibrotic IPF and 28 no-IPF patients, and 30 healthy controls were enrolled. Exclusion criteria were autoimmune systemic diseases, coronary disease, heart failure, primary cardiomyopathies, chronic obstructive lung diseases, pulmonary embolism, primary pulmonary hypertension. Lung damage was evaluated by diffusion capacity for carbon monoxide (DLCOsb). All participants underwent an echo-Doppler exam including 2D global longitudinal strain (GLS) of both ventricles and 3D echocardiographic RV ejection fraction (RVEF). Results: We observed LV diastolic dysfunction in IPF and no-IPF, and LV GLS but not LV EF reduction only in IPF. RV diastolic and RV GLS abnormalities were observed in IPF versus both controls and no-IPF. RV EF did not differ significantly between IPF and no-IPF. DLCOsb and RV GLS were associated in the pooled pulmonary fibrosis population and in the IPF subgroup (&beta = 0.708, p < 0.001), independently of confounders including pulmonary arterial systolic pressure. Conclusion: Our data highlight the unique diagnostic capabilities of GLS in distinguishing early cardiac damage of IPF from no-IPF patients. |
| Databáze: | OpenAIRE |
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