Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens
| Autor: | Gerard F. Graminski, Solveig LaTurner, Maralee Mcvean, Josh R. Ziemer, Scott M. Vanderwerf, Mark R. Burns, Jay R. Carreon, Bruce H. Devens, Reitha S. Weeks, C. Lance Carlson |
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| Rok vydání: | 2002 |
| Předmět: |
Tertiary amine
Stereochemistry Nitrogen Clinical Biochemistry Pharmaceutical Science Apoptosis Diamines Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery medicine Tumor Cells Cultured Humans Molecular Biology chemistry.chemical_classification Aryl Organic Chemistry Enzyme chemistry Mechanism of action Molecular Medicine medicine.symptom Drug Screening Assays Antitumor Polyamine Aliphatic compound Intracellular |
| Zdroj: | Bioorganicmedicinal chemistry letters. 12(9) |
| ISSN: | 0960-894X |
| Popis: | A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents and the distance between amino groups the most potent analogues were analyzed biologically and were shown to induce apoptosis. These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues. |
| Databáze: | OpenAIRE |
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