A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
| Autor: | Lionello Ruggeri, Alessandra Vitelli, Alfredo Nicosia, Armin Lahm, Elena Fattori, Alessandra Luzzago, Stefania Capone, Elisabetta Sporeno, Rosalba Tafi, Antonella Folgori, Stefano Colloca, Monica Pezzanera, Riccardo Cortese, Annalisa Meola, Mirko Arcuri, Bruno Bruni Ercole |
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| Přispěvatelé: | Folgori, A., Capone, S., Ruggeri, L., Meola, A., Sporeno, E., Ercole, Bb, Pezzanera, M., Tafi, R., Arcuri, M., Fattori, E., Lahm, A., Luzzago, L., Vitelli, A., Colloca, S., Cortese, R., Nicosia, Alfredo |
| Rok vydání: | 2005 |
| Předmět: |
Viral Hepatitis Vaccines
Pan troglodytes Hepatitis C virus medicine.medical_treatment T-Lymphocytes Molecular Sequence Data Heterologous Viremia Hepacivirus Biology CD8-Positive T-Lymphocytes Cross Reactions medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Epitopes Immune system Immunity medicine Animals Humans Amino Acid Sequence Immunity Cellular virus diseases General Medicine Immunotherapy Hepatitis C Hepatitis C Antibodies Hepatitis C Chronic medicine.disease Virology Immunology RNA Viral Hepatitis C Antigens |
| Zdroj: | Nature medicine. 12(2) |
| ISSN: | 1078-8956 |
| Popis: | Three percent of the world's population is chronically infected with the hepatitis C virus (HCV) and at risk of developing liver cancer. Effective cellular immune responses are deemed essential for spontaneous resolution of acute hepatitis C and long-term protection. Here we describe a new T-cell HCV genetic vaccine capable of protecting chimpanzees from acute hepatitis induced by challenge with heterologous virus. Suppression of acute viremia in vaccinated chimpanzees occurred as a result of massive expansion of peripheral and intrahepatic HCV-specific CD8(+) T lymphocytes that cross-reacted with vaccine and virus epitopes. These findings show that it is possible to elicit effective immunity against heterologous HCV strains by stimulating only the cellular arm of the immune system, and suggest a path for new immunotherapy against highly variable human pathogens like HCV, HIV or malaria, which can evade humoral responses. |
| Databáze: | OpenAIRE |
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