Application of a Nanotechnology-Based, Point-of-Care Diagnostic Device in Diabetic Kidney Disease
| Autor: | Suraj Hebbar, Thummala Kamala, Vasanthi Nath, Sri Srikanta, Sachin Panwar, Ananthram Bhat, Babithadevi Thyagaraj, Indranil Dasgupta, Urmila Anandh, Reshma Vijay, Kavitha Muniraj, Vinay Kumar, Madhumati S Vaishnav, Sapna Manjunath, P. R. Krishnaswamy, Navakanta Bhat, Muralidharakrishna Chikkamoga Siddaiah, Chandraprabha siddalingappa |
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| Rok vydání: | 2018 |
| Předmět: |
Nephrology
obesity medicine.medical_specialty Nanotechnology 030204 cardiovascular system & hematology albuminuria Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Clinical Research Internal medicine Diabetes mellitus medicine 030212 general & internal medicine Prospective cohort study Point of care diabetes business.industry diabetic nephropathy medicine.disease anemia Albuminuria Microalbuminuria medicine.symptom business chronic kidney disease Kidney disease |
| Zdroj: | Kidney International Reports |
| ISSN: | 2468-0249 |
| DOI: | 10.1016/j.ekir.2018.05.008 |
| Popis: | Introduction Early detection of diabetes mellitus (DM) and diabetic kidney disease (DKD) is important for preventing end-stage renal failure and reducing cardiovascular complications. Availability of a validated point-of-care (PoC) device that can measure various DKD markers would be useful in this respect, especially in resource-poor parts of the world. Methods We validated a novel nanotechnology-based multianalyte PoC device (minimally invasive and does not require trained medical personnel) against laboratory gold standard tests for the detection of 5 biomarkers related to management of DM and DKD. The prospective study was funded by an International Society of Nephrology American Nephrologists of Indian Origin grant in 2 phases: (i) proof of concept: random samples were tested for the analytes with the PoC device and correlated with the laboratory gold standard; and (ii) clinical validation in a well-characterized cohort of patients. A nonenzymatic- and nonantibody-based electrochemical PoC device for quantitative measurement of markers—glycosylated hemoglobin (HbA1c), hemoglobin, serum albumin, microalbuminuria, urine creatinine, and albumin-to-creatinine ratio−was developed and used in this study. The disposable strips were interfaced with a multipotentiostat hand-held PoC device (3.7-V rechargeable lithium battery, 5-inch touch screen, Bluetooth enabled) working in amperometry mode, which provided the results in |
| Databáze: | OpenAIRE |
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