Evaluation of Initial Telomere Length and Changes after Transplantation in Adult Double-Unit Cord Blood Transplant Recipients
| Autor: | Ahmet Zehir, Malcolm A.S. Moore, Marissa Lubin, Beth Ashbridge, Juliet N. Barker |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Telomerase Pathology medicine.medical_specialty Transplantation Conditioning Cord Blood Stem Cell Transplantation Biology Article Andrology Telomere Homeostasis medicine Humans Retrospective Studies Transplantation Telomere length Graft Survival Cord blood Hematology Middle Aged Myeloablative Agonists Telomere Transplant Recipients Haematopoiesis Treatment Outcome Allogeneic transplantation Hematologic Neoplasms Leukocytes Mononuclear Female Stem cell Unrelated Donors |
| Zdroj: | Biology of Blood and Marrow Transplantation. 21:1334-1336 |
| ISSN: | 1083-8791 |
| Popis: | Cord blood (CB) leukocytes have inherent telomere length (TL) variation, and CB hematopoietic stem cells (HSC) can maintain high telomerase levels preventing telomere attrition in vitro. We evaluated TL changes in 13 adult double-unit CB transplant (CBT) recipients. In the 26 units, we observed a marked variation in CB TL at thaw (median, 9.99 kilobases [kb]; range, 6.85 to 13.5). All 13 patients engrafted. Of 11 engrafting with 1 unit, there was no correlation between unit dominance and TL (mean dominant unit TL, 8.84 kb ± 1.76; mean nonengrafting unit TL, 10.3 kb ± 1.81; P = .77). Serial measurements of TL up to 1 year after CBT demonstrated an overall mean 3.04 kb ± .16 TL decrease with only 1 patient exhibiting telomere maintenance. In summary, initial TL does not predict CB unit dominance. Moreover, our analysis suggests neonatal hematopoiesis makes a transition to an HSC characterized by changes in average TL and potentially low telomerase asymmetric cell division in adult CBT recipients. Further investigation of alterations in telomere length and its clinical implications after transplantation of this observation are indicated. |
| Databáze: | OpenAIRE |
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